People in the Renaissance had their very own wacky ideas about the meaning of moles. Quack Richard Sanders invented a faddish "system" by which he claimed people could use facial moles to find out where people had corresponding birthmarks.
At the time, birthmarks were believed to give deep insights into personality. So if you could find out where someone's moles were, you'd know where their birthmarks were, too, and then could use them to discern whether someone would make a good husband, business partner, etc.
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